HBV-associated DLBCL of poor prognosis: advance in pathogenesis, immunity and therapy
نویسندگان
چکیده
Advanced studies have shown a biological correlation between hepatitis B virus (HBV) and B-cell lymphoma, especially diffuse large lymphoma (DLBCL). Patients with DLBCL infected HBV (HBV-associated DLBCL) are clinically characterized by an advanced clinical stage, poor response to front-line immunochemotherapy regimens, worse prognosis. HBV-associated often exhibits abnormal activation of the nuclear factor kappa pathway as well mutations in oncogenes, including Myc BCL-6 . Currently, there is no consensus on any specific effective treatment for DLBCL. Therefore, this review, we comprehensively mechanistically analyzed natural history infection immunity, HBV-mediated immune escape, epigenetic alterations, dysregulated signaling pathways, potential therapeutic approaches We hope that improved understanding biology would lead development novel approaches, enhance number trials, improve prognosis disease.
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2023
ISSN: ['1664-3224']
DOI: https://doi.org/10.3389/fimmu.2023.1216610